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Cancer Rhabdomyosarcoma is a difficult-to-treat soft tissue pediatric tumor. In a particular subtype of this cancer, a fusion protein generated by a chromosomal abnormality drives chemoresistance and aggressive progression. Bharathy… Click to show full abstract
Cancer Rhabdomyosarcoma is a difficult-to-treat soft tissue pediatric tumor. In a particular subtype of this cancer, a fusion protein generated by a chromosomal abnormality drives chemoresistance and aggressive progression. Bharathy et al. investigated why the histone deacetylase inhibitor entinostat shows promise in treating this rhabdomyosarcoma subtype. Entinostat altered epigenetic regulation to inhibit translation of the fusion protein. Without the fusion protein, rhabdomyosarcoma growth in mouse models slowed, and tumors were sensitized to the chemotherapeutic drug vincristine. Sci. Signal. 11 , eaau7632 (2018).
Journal Title: Science
Year Published: 2018
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