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Inflammation Chronic occupational exposure to manganese is associated with the development of Parkinson's disease. Sarkar et al. found that exposure of primed microglia or mice to manganese increased the levels… Click to show full abstract
Inflammation Chronic occupational exposure to manganese is associated with the development of Parkinson's disease. Sarkar et al. found that exposure of primed microglia or mice to manganese increased the levels and activation of the NLRP3 inflammasome, an inflammation-promoting protein complex. Manganese treatment of microglia caused mitochondrial dysfunction and the release of exosomes containing the inflammasome adaptor protein ASC. Serum exosomes from welders contained more ASC and were more inflammatory than those from normal donors. Sci. Signal. 12 , eaat9900 (2019).
Journal Title: Science
Year Published: 2019
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