LAUSR

Cancer Hypoxic solid tumors develop a dysfunctional vasculature that prevents efficient chemotherapeutic penetration. Kugeratski et al. analyzed the proteome and secretome of cancer-associated fibroblasts, a prominent cell type in the tumor stroma. Hypoxia increased the levels of a protein called hypoxia-induced angiogenesis regulator (HIAR) in cancer-associated fibroblasts. HIAR promoted the release of the pro-angiogenic factor VEGF from these cells and induced VEGF-dependent signaling in endothelial cells. Thus, HIAR could be targeted by antiangiogenic therapy, which has been unsuccessful when directly targeting VEGF signaling. Sci. Signal. 12 , eaan8247 (2019).