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Tumor Immunotherapy An adoptive cellular therapy that expands clonal T cells could help fight deadly heterogeneous brain tumors, medulloblastoma, and glioblastoma. Working in mice, Flores et al. used dendritic cells… Click to show full abstract
Tumor Immunotherapy An adoptive cellular therapy that expands clonal T cells could help fight deadly heterogeneous brain tumors, medulloblastoma, and glioblastoma. Working in mice, Flores et al. used dendritic cells expressing tumor RNA to expand polyclonal T cells that quickly react against a variety of different antigens within different brain tumors. Promising results were also obtained in a patient with recurrent medulloblastoma. Although previous adoptive T cell therapies have proven effective against several advanced cancers, the current method could provide patients with effective T cell therapy for brain tumors. Sci. Adv. 10.1126/sciadv.aav9879 (2019).
Journal Title: Science
Year Published: 2019
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