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From genetics to material to behavior

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Biotechnology Introducing new genes into an organism can endow new biochemical functions or change the patterns of existing functions, but extending these manipulations to structure at the tissue level is… Click to show full abstract

Biotechnology Introducing new genes into an organism can endow new biochemical functions or change the patterns of existing functions, but extending these manipulations to structure at the tissue level is challenging. Combining genetic engineering and polymer chemistry, Liu et al. directly leveraged complex cellular architectures of living organisms to synthesize, fabricate, and assemble bioelectronic materials (see the Perspective by Otto and Schmidt). An engineered enzyme expressed in genetically targeted neurons synthesized conductive polymers in tissues of freely moving animals. These polymers enabled modulation of membrane properties in specific neuron populations and manipulation of behavior in living animals. Science , this issue p. [1372][1]; see also p. [1303][2] [1]: /lookup/doi/10.1126/science.aay4866 [2]: /lookup/doi/10.1126/science.abb0216

Keywords: material behavior; science; genetics; chemistry; genetics material

Journal Title: Science
Year Published: 2020

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