LAUSR

Populations North America has a long history of migration, movement, and admixture. However, how indigenous people and the continuous waves of global migration shaped the modern United States is poorly understood. Dai et al. analyzed genetic data from more than 32,000 individuals registered with the National Geographic Genographic Project. The authors linked population structure to the genetics of individuals, location of birth, and geography of the United States, including previously underrepresented populations of Asian and Middle Eastern ancestry. From this analysis, the authors show how population substructure reflects historical events, such as the slave trade with Africa. Locales of high genetic similarity were found, and, interestingly, Latinos showed a range of differing geographical and genetic histories. This fine map of U.S. population structure can aid in personalized medicine by providing relevant population-specific information from underrepresented groups within the United States. Am. J. Hum. Genet. 106 , 371 (2020).