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Immunology Commensal bacteria in the small intestine are known to help shape immune responses. Less well understood is whether the microbiota residing in the stomach are similarly immunoregulatory. Satoh-Takayama et… Click to show full abstract
Immunology Commensal bacteria in the small intestine are known to help shape immune responses. Less well understood is whether the microbiota residing in the stomach are similarly immunoregulatory. Satoh-Takayama et al. report that commensal bacteria can indeed regulate group 2 innate lymphoid cell (ILC2) homeostasis in the stomach. Furthermore, Helicobacter pylori , a pathogen responsible for gastritis and gastric cancer in humans, rapidly induces stomach ILC2 proliferation and activation in mice in an interleukin-7 (IL-7)– and IL-33–dependent manner. IL-5 production by ILC2 triggers B cell secretion of immunoglobulin A, which plays a role in H. pylori containment. ILC2 and commensal bacteria in the stomach may therefore serve as targets for various gastrointestinal disorders. Immunity 52 , 635 (2020).
Journal Title: Science
Year Published: 2020
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