LAUSR

Cancer Tumor neoantigens are cancer-specific antigens that are not found in healthy cells and play a major role in anticancer immune responses. Immunotherapies such as cancer vaccines can be based on known neoantigens, but it is often difficult to identify suitable targets. By using a bioassay called ATLAS, Lam et al. identified potential neoantigens in patients with lung cancer, and then characterized the immune responses to these antigens in a murine tumor model. A similar approach was applied to patients with multiple cancer types who were participating in a cancer vaccine trial. ATLAS-identified neoantigens include promising immunogenic candidates for vaccination that offer safe targets and potential for good clinical responses. Cancer Discov. 10.1158/2159-8290.CD-20-0377 (2021).