LAUSR

Coronavirus The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein mediates host cell entry and contains key epitopes for antibody binding. Emerging SARS-CoV-2 variants, which seem to have originated in immunocompromised patients with prolonged infections, have mutations in the spike protein. Some of these mutations recur in independent lineages and some may compensate for deleterious effects of others and thereby arise together. In a Perspective, McCormick et al. discuss emerging variants and mutations that may reduce antibody-mediated neutralization of the virus and, potentially, vaccine efficacy. Science , this issue p. [1306][1] [1]: /lookup/doi/10.1126/science.abg4493