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Response to Comment on “Innovative scattering analysis shows that hydrophobic disordered proteins are expanded in water”

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Best et al. claim that we provide no convincing basis to assert that a discrepancy remains between FRET and SAXS results on the dimensions of disordered proteins under physiological conditions.… Click to show full abstract

Best et al. claim that we provide no convincing basis to assert that a discrepancy remains between FRET and SAXS results on the dimensions of disordered proteins under physiological conditions. We maintain that a clear discrepancy is apparent in our and other recent publications, including results shown in the Best et al. comment. A plausible origin is fluorophore interactions in FRET experiments.

Keywords: comment; response comment; innovative scattering; comment innovative; scattering analysis; disordered proteins

Journal Title: Science
Year Published: 2018

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