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A better mouse model sheds light on immunotherapy's potential for treating metastatic cancer Over the past several decades, evidence has accumulated that stromal cells—the nonmutated cells that surround malignant cancer… Click to show full abstract
A better mouse model sheds light on immunotherapy's potential for treating metastatic cancer Over the past several decades, evidence has accumulated that stromal cells—the nonmutated cells that surround malignant cancer cells—are not mere bystanders in tumorigenesis. Instead, they play a crucial role in cancer progression. We now know that metastatic cancer cells must reprogram the tumor stroma, or tumor microenvironment (TME), before they can metastasize (1–3). They must also contend with the immune system that strives to limit tumor spreading. If the road to metastasis is full of intense obstacles, how can this disease be so devastating?
Journal Title: Science
Year Published: 2019
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