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Response to Comment on “Long-term measles-induced immunomodulation increases overall childhood infectious disease mortality”

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Thakkar and McCarthy suggest that periodicity in measles incidence artifactually drives our estimates of a 2- to 3-year duration of measles “immune-amnesia.” We show that periodicity has a negligible effect… Click to show full abstract

Thakkar and McCarthy suggest that periodicity in measles incidence artifactually drives our estimates of a 2- to 3-year duration of measles “immune-amnesia.” We show that periodicity has a negligible effect relative to the immunological signal we detect, and demonstrate that immune-amnesia is largely undetectable in small populations with large fluctuations in mortality of the type they use for illustration.

Keywords: term measles; response comment; long term; comment long; mortality; measles induced

Journal Title: Science
Year Published: 2019

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