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Three-dimensional genome structure of a single cell

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Chromosome organization in diploid cells reveals a structural basis for smell Since the 1880s, scientists such as Carl Rabl have been looking at cell nuclei under a microscope and speculating… Click to show full abstract

Chromosome organization in diploid cells reveals a structural basis for smell Since the 1880s, scientists such as Carl Rabl have been looking at cell nuclei under a microscope and speculating about their three-dimensional (3D) structure. We now know that each nucleus in our body carries 6 billion base pairs (bp) of DNA, which would be 2 m long if fully stretched. The linear sequence of this DNA was determined by the Human Genome Project in 2003; however, its 3D structure remains elusive.

Keywords: three dimensional; dimensional genome; genome structure; structure; cell

Journal Title: Science
Year Published: 2019

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