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Comment on “Aberrant type 1 immunity drives susceptibility to mucosal fungal infections”

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Description Break et al. (Research Articles, 15 January 2021, eaay5731) suggest that chronic mucocutaneous candidiasis in humans with inborn errors of AIRE and autoimmune polyendocrine syndrome type 1 is due… Click to show full abstract

Description Break et al. (Research Articles, 15 January 2021, eaay5731) suggest that chronic mucocutaneous candidiasis in humans with inborn errors of AIRE and autoimmune polyendocrine syndrome type 1 is due to excessive interferon-γ production and not to autoantibodies neutralizing interleukin-17 cytokines. We argue that both claims are not conclusively supported by their data and are at odds with 35 years of study.

Keywords: aberrant type; comment aberrant; drives susceptibility; immunity drives; type immunity; type

Journal Title: Science
Year Published: 2021

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