LAUSR

Description Understanding moral acceptability and willingness to use is crucial for informing policy For decades, people have used genetic information to exercise control over the kinds of children they will have. These technologies have largely targeted chromosomal and monogenic disorders and traits; but most human phenotypes are highly polygenic (and influenced by the environment). One technology that targets the entire genome—preimplantation genetic testing for polygenic risk (PGT-P)—uses polygenic indexes (PGIs) to predict the expected value of the phenotype(s) that would arise for each embryo if successfully transferred; parents can use these predictions to select an embryo for in vitro fertilization (IVF). Seeing gaps in evidence and analysis relevant for potential policy discussions around PGT-P, we conducted a survey of public attitudes. Our data suggest that it would be unwise to assume that use of PGT-P—even for controversial traits—will be limited to idiosyncratic individuals, or that it has little potential to cause or contribute to society-wide changes and inequities.