LAUSR

Description Cell atlases of human tolerogenic milieus guide transformative immunotherapies The ability to distinguish between self and nonself is a fundamental function of the immune system. Yet, in a few special situations, nonself antigens must be safely harbored in the body. This phenomenon of immunotolerance is crucial for the placenta, where the fetal genome is safe from attack by the maternal immune system. It is also relevant in the testis, where the synthesis of meiosis-associated neoantigens occurs during puberty after the establishment of self-tolerance.