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Autophagy and mTORC1 signaling are mediated by distinct p62 protein species (Sanchez-Garrido et al., in 4 December 2018 issue). In human cells, the p62 protein acts as an adaptor in… Click to show full abstract
Autophagy and mTORC1 signaling are mediated by distinct p62 protein species (Sanchez-Garrido et al., in 4 December 2018 issue). In human cells, the p62 protein acts as an adaptor in various signaling pathways as well as a receptor for selective autophagy. In this issue of Science Signaling, Sanchez-Garrido et al. show that proteolytic cleavage of p62 by caspase-8 determines whether p62 functions as an mTORC1 signaling adaptor or autophagy receptor.
Keywords:
mtorc1 signaling;
mtorc1;
labor mtorc1;
division labor;
signaling autophagy
Journal Title: Science Signaling
Year Published: 2018
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Journal Title: Science Signaling
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!