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Rounding out cyclic dinucleotide signaling in Clostridioides difficile: A role and a mechanism for c-di-AMP

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The second messenger c-di-AMP contributes to various homeostatic and stress responses in bacteria. In this issue of Science Signaling, Oberkampf et al. have identified it as a mediator of osmotic… Click to show full abstract

The second messenger c-di-AMP contributes to various homeostatic and stress responses in bacteria. In this issue of Science Signaling, Oberkampf et al. have identified it as a mediator of osmotic stress and bile salt resistance in the opportunistic pathogen Clostridioides difficile, with additional roles in cell wall homeostasis and biofilm formation. Description Biological roles for c-di-AMP in C. difficile are revealed (Oberkampf et al., in 6 September 2022).

Keywords: signaling clostridioides; difficile role; clostridioides difficile; cyclic dinucleotide; dinucleotide signaling; rounding cyclic

Journal Title: Science Signaling
Year Published: 2022

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