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Mutations in the HIV-1 3′-Polypurine Tract and Integrase Strand Transfer Inhibitor Resistance

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Integrase strand-transfer inhibitors (INSTIs), in combination with other antivirals, are widely used for the treatment of HIV-1-infected individuals. HIV-1 resistance to INSTIs is typically associated with mutations in the viral… Click to show full abstract

Integrase strand-transfer inhibitors (INSTIs), in combination with other antivirals, are widely used for the treatment of HIV-1-infected individuals. HIV-1 resistance to INSTIs is typically associated with mutations in the viral integrase gene [1].….

Keywords: integrase strand; strand transfer; resistance

Journal Title: Antimicrobial Agents and Chemotherapy
Year Published: 2021

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