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ABSTRACT When overproduced, the multidrug efflux system MexEF-OprN increases the resistance of Pseudomonas aeruginosa to fluoroquinolones, chloramphenicol, and trimethoprim. In this work, we demonstrate that gain-of-function mutations in the regulatory… Click to show full abstract
ABSTRACT When overproduced, the multidrug efflux system MexEF-OprN increases the resistance of Pseudomonas aeruginosa to fluoroquinolones, chloramphenicol, and trimethoprim. In this work, we demonstrate that gain-of-function mutations in the regulatory gene mexT result in oligomerization of the LysR regulator MexT, constitutive upregulation of the efflux pump, and increased resistance in clinical isolates.
Keywords:
pseudomonas aeruginosa;
activation mext;
constitutive activation;
clinical isolates;
mexef oprn;
mext amino
Journal Title: Antimicrobial Agents and Chemotherapy
Year Published: 2018
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Journal Title: Antimicrobial Agents and Chemotherapy
Year Published: 2018
Link to full text (if available)
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recommendations!