LAUSR.org creates dashboard-style pages of related content for over 1.5 million academic articles. Sign Up to like articles & get recommendations!

uvrY Deletion and Acetate Reduce Gut Colonization of Crohn’s Disease-Associated Adherent-Invasive Escherichia coli by Decreasing Expression of Type 1 Fimbriae

Photo from wikipedia

Adherent-invasive Escherichia coli (AIEC) is involved in onset and/or exacerbation of Crohn’s disease (CD). AIEC adapts to the gut environment by altering gene expression programs, leading to successful gut-lumen colonization.… Click to show full abstract

Adherent-invasive Escherichia coli (AIEC) is involved in onset and/or exacerbation of Crohn’s disease (CD). AIEC adapts to the gut environment by altering gene expression programs, leading to successful gut-lumen colonization. ABSTRACT Adherent-invasive Escherichia coli (AIEC) is involved in onset and/or exacerbation of Crohn’s disease (CD). AIEC adapts to the gut environment by altering gene expression programs, leading to successful gut-lumen colonization. However, the underlying mechanism of gut colonization is still far from clarified. Here, we show the role of UvrY, a response regulator of bacterial two-component signal transduction systems, in AIEC gut colonization. An AIEC mutant lacking the uvrY gene exhibited impairment of competitive colonization in the murine intestinal tract. UvrY contributes to functional expression of type 1 fimbriae by activating expression of small RNA CsrB, which confers adherence and invasion into epithelial cells on AIEC. In contrast, acetate suppresses the UvrY-dependent expression of type 1 fimbriae, resulting in less efficient cell invasion and attenuated gut colonization. Our findings might lead to therapeutic interventions for CD, in which inhibitions of UvrY activation and acetate supplementation reduce the colonization levels of AIEC by decreasing type 1 fimbria expression.

Keywords: colonization; expression; invasive escherichia; type; adherent invasive; gut colonization

Journal Title: Infection and Immunity
Year Published: 2022

Link to full text (if available)


Share on Social Media:                               Sign Up to like & get
recommendations!

Related content

More Information              News              Social Media              Video              Recommended



                Click one of the above tabs to view related content.