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Abstract A new method has been developed that enables synthesizing peptides with desired physicochemical properties, for example, with high affinity to one target protein and low affinity to other proteins,… Click to show full abstract
Abstract A new method has been developed that enables synthesizing peptides with desired physicochemical properties, for example, with high affinity to one target protein and low affinity to other proteins, and determining the stability of protein complexes with point substitutions of amino acid residues taking into account the three-dimensional structure of the complex by the example of the Bcl2 family, thereby achieving targeted therapeutic selectivity in the treatment of various pathologies.
Keywords:
stability protein;
effect point;
example;
family;
simulation effect
Journal Title: Technical Physics
Year Published: 2020
Link to full text (if available)
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Journal Title: Technical Physics
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!