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Synthesis and Characterization of Disulfide-Schiff Base Derivatives and in vitro Investigation of Their Antibacterial Activity Against Multidrug-Resistant Acinetobacter baumannii Isolates: A New Study

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In this study two different methods without a catalyst and with a CeO2 nano catalyst were used for the synthesis of dimeric disulfide-Schiff bases. The dimeric disulfide-Schiff base derivatives were… Click to show full abstract

In this study two different methods without a catalyst and with a CeO2 nano catalyst were used for the synthesis of dimeric disulfide-Schiff bases. The dimeric disulfide-Schiff base derivatives were characterized by FT-IR, NMR, and MS spectra, and elemental analysis. The disulfide-Schiff bases and their derivatives 2–5c were screened for in vitro antibacterial activity against 40 multidrug-resistant strains of Acinetobacter baumannii, and their minimum inhibitory concentrations were determined. Most of products exhibited high antibacterial activity against Acinetobacter baumannii.

Keywords: antibacterial activity; base derivatives; disulfide schiff; acinetobacter baumannii; schiff base

Journal Title: Russian Journal of General Chemistry
Year Published: 2018

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