A series of thieno-pyrimidine derivatives are synthesized from 5′-amino-2,3′-bithiophene-4′-carboxylate via the corresponding intermediate N-benzoylated carboxamide derivatives. The target compounds are tested for antibacterial and antifungal activity. Some of the synthesized… Click to show full abstract
A series of thieno-pyrimidine derivatives are synthesized from 5′-amino-2,3′-bithiophene-4′-carboxylate via the corresponding intermediate N-benzoylated carboxamide derivatives. The target compounds are tested for antibacterial and antifungal activity. Some of the synthesized compounds demonstrate potent antibacterial activity with LD50 comparable with the reference drug indomethacin.
Keywords:
thieno pyrimidine;
derivatives antimicrobial;
substituted thieno;
synthesis new;
pyrimidine derivatives;
new substituted
Journal Title: Russian Journal of General Chemistry
Year Published: 2019
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Journal Title: Russian Journal of General Chemistry
Year Published: 2019
Link to full text (if available)
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recommendations!