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Some Features of the Reaction of 6-Methyl-2S-substituted Pyrimidin-4-ols with the Vilsmeier–Haack Reagent

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Abstract Formylation of 6-methyl-2 S -substituted pyrimidin-4-ols under the conditions of the Vilsmeier–Haack reaction leads to the formation of nucleophilic substitution products of the hydroxyl group. The formation of the… Click to show full abstract

Abstract Formylation of 6-methyl-2 S -substituted pyrimidin-4-ols under the conditions of the Vilsmeier–Haack reaction leads to the formation of nucleophilic substitution products of the hydroxyl group. The formation of the expected formylation products does not occur.

Keywords: methyl substituted; substituted pyrimidin; pyrimidin ols; vilsmeier haack

Journal Title: Russian Journal of General Chemistry
Year Published: 2020

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