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Using Fura-2AM microfluorimetry, it was shown for the first time that neuroleptic chlorpromazine causes intracellular Ca2+ concentration increase in macrophages due to Ca2+ mobilization from intracellular Ca2+ stores and subsequent… Click to show full abstract
Using Fura-2AM microfluorimetry, it was shown for the first time that neuroleptic chlorpromazine causes intracellular Ca2+ concentration increase in macrophages due to Ca2+ mobilization from intracellular Ca2+ stores and subsequent Ca2+ entry from the external medium. Chlorpromazine-induced Ca2+ entry is inhibited by La3+ and 2-aminoethoxydiphenyl borate and is associated with Ca2+ store depletion.
Keywords:
intracellular ca2;
effect chlorpromazine;
ca2;
ca2 concentration
Journal Title: Doklady Biochemistry and Biophysics
Year Published: 2017
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Journal Title: Doklady Biochemistry and Biophysics
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!