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Using voltage-clamp technique, the involvement of sigma-1 receptors in the regulation of Na+ transport in frog skin by the immunomodulatory drug glutoxim was investigated. We have shown for the first… Click to show full abstract
Using voltage-clamp technique, the involvement of sigma-1 receptors in the regulation of Na+ transport in frog skin by the immunomodulatory drug glutoxim was investigated. We have shown for the first time that preincubation of the frog skin with the sigma-1 receptor antagonists haloperidol and chlorpromazine attenuates the stimulatory effect of glutoxim on the Na+ transport. The results suggest the possible involvement of the sigma-1 receptors in the regulation of Na+ transport in frog skin epithelium by glutoxim.
Keywords:
transport frog;
glutoxim;
transport;
frog skin;
sigma
Journal Title: Doklady Biochemistry and Biophysics
Year Published: 2019
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Journal Title: Doklady Biochemistry and Biophysics
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!