LAUSR

Background Radiographic osteoarthritis (OA) severity and pain play an important role in the indication for total knee arthroplasty (TKA). It is however unkonw whether preoperative self-reported clinical pain modifies the effect of radiographic OA severity on postoperative pain and function in OA patients after TKA. Objectives To investigate whether preoperative self-reported clinical pain modified the effect of radiographic OA severity on postoperative pain and function in OA patients 1 year after TKA. Methods Data from the Longitudinal Leiden Orthopaedics Outcomes of Osteoarthritis Study (LOAS), a multicentre cohort study on outcomes after TKA were used. Radiographic OA severity was assessed with the Kellgren and Lawrence (KL) score (0–4). Pain and function were evaluated with the Knee Injury and Osteoarthritis Outcome Score (KOOS). After adjustment for confounders (BMI, age, gender and Mental Health Component Scores from the Short Form-12), multivariate linear regression analyses with an interaction term between KL-score and preoperative pain were performed. Results 560 patients were included. Both KL-score and preoperative pain were associated with postoperative pain (β:6.1, 95% CI: 1.7–10.5 and β:0.4, 95% CI 0.1–0.7)) and function (β:8.0, 95% CI: 3.7–12.3 and β 0.5, 95% CI 0.2–0.8). A trend towards effect modification of preoperative pain on the association between KL-score and postoperative pain (β −0.1, 95% CI −0.2–0.0) and function (β −0.1, 95% CI −0.2–0.0) was found indicating that effect of preoperative pain on postoperative pain and function seems to become less important when more severe radiographic severity is present. Conclusions Patients with less preoperative pain and higher KL grades have better function and pain outcomes 12 months after TKA. However preoperative pain seems less importance in patients with more severe radiographic OA. Acknowledgements This study was supported by the Dutch Arthritis Association [grant number LLP13]. Disclosure of Interest None declared