LAUSR

Background Treatment and evolution of Rheumatoid Arthritis (RA) have had an important change in the last years. However the trend of amyloidosis, habitually related to long-standing and active RA, in Spain is unknown. Objectives To analyse the incidence and trend of hospital admissions for amyloidosis in RA patients in Spain from 1999 to 2015. Methods We performed an observational retrospective population study analysing the spanish administrative database that includes a Minimun Basic Data Set (MBDS) of hospital admissions of RA patients from 1999 to 2015. We selected the MBDSs for amyloidosis. Cases were identified by the presence in primary and secondary diagnosis of its ICD9 code. The population at risk was estimated with an estimated prevalence of RA of 0,5% (0,8% women and 0,2% men). Crude and adjusted rates were calculated, and the trend was analysed using the Generalised Linear Model (GLM) with the year as the analysis variable. SPSS version 20 (SPSS Inc, Chicago, IL) was used. Results 338.343 RA hospital admissions were detected, being 3085 (0,9%) due to amyloidosis with 2298 (74,5%) women and 787 (25,5%) men. Mean age 65,42 (SD 13,08). There were 366 (11,9%) deaths. Age-adjusted rate during the period was 122,87/105 inhab. per year (98,96 women and 146,79 men). Amyloidosis age-adjusted rate decreased from 138,88/105 inhab. per year in 1999 to 71,47 in 2015, both women (128,18 in 1999 to 61,35 in 2015) and men (162,36 in 1999 to 107,95 in 2015). An annual decrease in the amyloidosis rate of 4,6% is estimated (RRI 0,953; CI 95% 0,939–0,968). Conclusions In Spain from 1999 to 2015 amyloidosis hospital admissions in patients with RA decreased, with an estimation of 4,6% annual reduction. This finding concurs with a greater knowledge of RA and its treatment advances with ”treat-to-target” strategies. Disclosure of Interest None declared