LAUSR

Background Hyperuricemia induces gout and kidney stones and accelerates the progression of renal diseases. Hyperuricemia is a common multifactorial disorder having several environmental factors such as sex, diet, alcohol consumption, and obesity. The increasing prevalence of hyperuricemia in recent years is thought to be due to environmental factors, particularly diet. Based on the reported association between sugar-sweetened beverages and hyperuricemia in epidemiological studies, it has been hypothesised that fructose, the primary sweetener in sugar-sweetened beverages, directly increase plasma urate levels. Objectives The aim of this study was to investigate whether and how fructose induces an increase in plasma urate levels. Methods Urate in plasma and urine were measured after fructose, glucose, or water was administered to Sprague-Dawley rats at doses of 2.5 or 7.5 g/kg at a time. Intestinal closed loops were made using approximately 10 cm of ileum. Phosphate buffered saline was injected into each intestinal loop. After 4 hours, urate levels in the loops were measured. Results Plasma urate level was significantly increased within 15–30 min by oral administration of fructose, without an increase in urinary and intestinal urate excretion, and a decreasing tendency of urate clearance was observed. These actions were evident at a dose of 7.5 g/kg body weight. The absence of an increase in urinary and intestinal urate excretion indicated that an increase in urate production did not result in the increase in plasma urate level. In the meantime, a decrease in urate clearance was suggested to cause the increase in plasma urate level. Conclusions The present study demonstrated that oral intake of fructose induces an increase in plasma urate level within a short time and that a decrease in renal urate clearance could mainly work for that. Disclosure of Interest None declared