LAUSR

Objectives To investigate the primary respiratory manifestations (PRM) in SLE. Methods All patients in the RELESSER cohort were retrospectively investigated for the presence of PRM Results At least one PRM was present in 11.3% (365/3215) of cases. The most common was pleurisy, occurring in 21.1% of patients, followed by ALP in 3.6%, PE in 2.9%, PPH 4%, DILD in 2%, DAH in 0.8%, and SLS in 0.8%. The variables associated with the presence of PPM are shown in the following table 1: Odds Ratio 95% ConfidenceInterval P Age 1,03 1,02–1,04 0.000 SLEDAI score 1,03 1,00–1,07 0,02 Raynaud phenomenon 1,41 1,09–1,84 0,01 Severe nephritis 1,56 1,18–2,06 0002 Secondary APS 2,2 1,63–2,97 0.000 Anti-RNP positivity 1,32 1,00–1,75 0054 Cardiac disease 2,81 1,90–4,16 0000 Vasculitis 1,81 1,25–2,62 0002 Hematologic abnormalities 1,31 1,00–1,71 0048 Neuropsychiatric manifestations 1,49 1,11–2.02 0009 Gastrointestinal involvement 2,05 1,14–3,67 0016 After adjusting for known confounders in the multivariable model, PPM remained a risk factor for diminished survival (HR: 3.13). Conclusions PPM independently contributed to a decreased survival in SLE Disclosure of Interest None declared