We are grateful to Dr Inamo1 for his interest in our article. We agree and acknowledged in our manuscript that our study design did not allow us to assess a… Click to show full abstract
We are grateful to Dr Inamo1 for his interest in our article. We agree and acknowledged in our manuscript that our study design did not allow us to assess a causal association. Our study described an increased relative abundance in Prevotella spp. in individuals in ‘preclinical rheumatoid arthritis (RA) stages’ using participants enrolled in a first-degree relatives of patients with RA (FDR-RA) cohort.2 The microbiota of individuals in preclinical RA stages were significantly altered compared with FDR-RA controls. In particular, bacteria of the Prevotellaceae family and associated taxa were enriched among individuals in preclinical stages of RA. Dr …
               
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