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Causal association of gut microbiome on the risk of rheumatoid arthritis: a Mendelian randomisation study.

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I read with interest the articles by Inamo1 and Alpizar-Rodriguez et al 2 regarding the effects of the gut microbiome on the risk of rheumatoid arthritis (RA). The Mendelian randomisation… Click to show full abstract

I read with interest the articles by Inamo1 and Alpizar-Rodriguez et al 2 regarding the effects of the gut microbiome on the risk of rheumatoid arthritis (RA). The Mendelian randomisation (MR) study suggested that dysbiosis may be a secondary phenomenon, rather than a trigger, in the pathogenesis of RA,1 while the cohort study by Alpizar-Rodriguez et al suggested a role for intestinal dysbiosis in the development of RA.2 However, some methodological issues in the MR study must be discussed. First, I applied a …

Keywords: microbiome risk; study; risk rheumatoid; arthritis mendelian; rheumatoid arthritis; gut microbiome

Journal Title: Annals of the rheumatic diseases
Year Published: 2020

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