LAUSR

Background Systemic autoimmune or granulomatous disorders related to biomaterials of human use have rarely been described Objectives The aim of this study was to report cases of autoimmune/inflammatory syndrome induced by adjuvants (ASIA) related to biomaterial injections and prostheses, mainly silicone, hyaluronic acid, acrylamides and methacrylate compounds in a Spanish patient cohort. Methods This study is a retrospective analysis of clinical, laboratory, histopathological and follow-up data of 50 cases of patients suffering from late-onset, non-infectious inflammatory/autoimmune disorders related to bioimplants. Late onset was defined as 3 months or more post injection. Data were obtained through a further non-systematic but comprehensive review of the literature. Fifty cases of late-onset adverse reactions related to biomaterial injections or prostheses were reviewed. Results All cases had systemic complaints that could be categorised as ASIA. In all but five patients, inflammatory features at the implantation site preceded distant or systemic manifestations. Abnormal blood tests were common. Localised inflammatory nodules and panniculitis in 88.88% evolved into a variety of disorders, viz., primary biliary cirrhosis, Sjögren’s syndrome, sarcoidosis, human adjuvant disease, vasculitis, inflammatory bowel syndrome and inflammatory polyradiculopathy. 11.11% cases presented primarily with systemic autoimmune disorders. Conclusion Biomaterials and prostheses can provoke late-onset systemic autoimmune disorders fulfilling ASIA criteria, or present primarily local/regional inflammatory reactions that may eventually evolve into systemic autoimmune and/or granulomatous disorders which fall under ASIA References [1] Hanke CW, Rohrich RJ, Busso M, Carruthers A, Carruthers J, Fagien S, et al. Facial soft-tissue fillers: assessing the state of the science conference proceedings report. J Am Acad Dermatol. 2011;64(4 Suppl):S53–65. [2] Ellis DA, Makdessian AS, Brown DJ. Survey of future injectables. Facial Plast Surg Clin North Am. 2001;9:405–11. [3] American Society of Plastic Surgery. Statistics of 2010, http://www.surgery.org/site/default/stats2010_1.pdf (2010, Accessed 01 Aug 2011). Disclosure of Interests None declared