LAUSR

Background The ratio of neutrophils to lymphocytes (NRL) is considered a novel inflammatory marker. Recently studies are ongoing for objective and easy markers (1) Objectives In this study, we aimed to identify the possible relationship between NRL and clinical characteristics inn patients with systemic sclerosis (SSc) Methods Our study is based on a retrospective analysis. We collected in a data base clinic and epidemiological characteristic of SSc patients. Fifty-two patients (46 female; 10 subset diffuse) with SSc were enrolled consecutively for analyser the correlations. We considered the correlation with NRL and skin core, ulcers, pitting scars, gastro-intestinal events, fibrosis on HTCR, respiratory parameters (FVC, DLCO), PAPs, diastolic abnormalities, capillaroscopy alterations and activity index (2). Student’s t-test was used for comparison averages, correlation among variables were assessed by Sperman’s correlation testing. Results: sociodemographic and clinical characteristic were reported in table 1. The correlation analysis statistically significant is summarized in table 2: NLR vs skin score, DLCO, PAPs, and activity index. The correlation analysis between NLR and presence of ulcers and pitting scars was considered not quite significant. There were no correlations between other parameters and NLR. Conclusion NLR values correlated negatively with DLCO value, and positively with PAP value, skin score and activity index NLR level may serve as inflammatory marker in patients with SSc. References [1] absenger G. et al. Br J Cancer2013; 109:395 [2] Valentini G. et al. Ann Rheum Dids2001; 60:592Table 1 Sociodemographic and clinical characteristics Patients n=52 Age (years) mean ±sd 53.58±13.99 Sex (M/F) 6/46 Disease duration (years) mean ±sd 8.68±9.6 WBC count (K/µL) mean ± sd 6748±2302 NLR, mean ± sd 2398±1290 Skin score, mean ±sd 3.94±6.26 DLCO% of predict, mean ±sd 71.4±23.4 PAPs mmHg, mean ±sd 19.9±19.1 Ulcers (yes/no) 5/47 Pitting scars (yes/no) 18/34 Cpillaroscopy alterations, normal/early/active/late 6/17/17/12 Activity index, mean ±sd 1.86±1.48 Tabel 2. Correlation analysis between NLR and skin score, DLCO, PAPs, activity index Skin score DLCO PAPs Activity index NLR r value 0.28 -0.30 0.29 0.28 p value 0.045 0.035 0.033 0.042 Disclosure of interests None declared