LAUSR

Background: The relative frequencies of co-morbidities like depression, anxiety, fatigue and sleep disturbance in RA, SLE and GPA are not fully elucidated. Objectives: To estimate and correlate the prevalence of depression, anxiety, fatigue and sleep disturbances in patients with RA, SLE and GPA by using time honored scales and PROMIS-HAQ1. Methods: This was a cross sectional study of 183 patients (RA – 57, SLE – 64, GPA – 62). Diagnosis and assessment of depression, insomnia, anxiety and fatigue was established by patient health questionnaire 9 (PHQ 9), Epworth sleepiness scale (ESS), generalized anxiety disorder assessment scale 7 (GAD 7) and fatigue severity scale (FSS) respectively. PROMIS-HAQ short form 8a was also used to diagnose depression, insomnia, anxiety and fatigue and its correlation with the above time honored scales was studied. Results: Mean age of RA, SLE and GPA patients was 45.5 ± 12, 31 ± 9.5 and 42.7 ± 13.5 years respectively. Mean disease duration was 5.7 ± 5.1, 3.3 ± 2.4 and 4.6 ± 4 years in RA, SLE and GPA respectively. Prevalence of depression, anxiety, fatigue, insomnia in RA, SLE and GPA as per standard scales and PROMIS HAQ is depicted in table 1. The corelation between the standard scales and PROMIS HAQ for depression [RA (r- .816, p< .001), SLE (r- 0.625, p< 0.001), GPA (r-0.772, p <0.001)], anxiety [RA (r- .804, P< .001), SLE (r- 0.709, p<0.001), GPA (0.888, p<0.001)], sleep disturbance [RA (r- .872, p<0.001), SLE (r- 0.784, p< 0.001), GPA (r-0.917, p <0.001)] and fatigue [RA (r- .815, p< .001), SLE (r- 0.798, p< 0.001), GPA (r-0.805, p <0.001)] was significant.Table 1 Prevalence of depression, anxiety, fatigue and insomnia by various scales Depression Anxiety Fatigue Sleep/Insomnia PHQ9 PROMIS HAQ GAD7 PROMIS HAQ FSS PROMIS HAQ ESS PROMIS HAQ RA 49.2% 35.1% 45.6% 38.5% 40.4% 49.1% 19.3% 17.5% SLE 60.9% 43.7% 51.6% 40.6% 51.6% 57.8% 15.6% 14.1% GPA 46.8% 21% 29.0% 24.0% 38.7% 40.3% 16.1% 12.9% Conclusion: Depression, anxiety, fatigue and sleep disturbance are common in RA, SLE and GPA. PROMIS HAQ has good correlation with time honoured scales for assesment of depression, anxiety, fatigue and sleep disturbance in these disorders. References [1] Cella D, Riley W, Stone a, et al. The Patient-Reported Outcomes Measurement information System (PROMIS) developed and tested its first wave of adult self-reported health outcome item banks: 2005-2008. J Clin Epidemiol2010;63:1179–94. Disclosure of interests: None declared