LAUSR

Background: Systemic lupus erythematosus (SLE) patients are at high risk of depression and anxiety. These two states cause severe loss of health related quality of life (HRQoL) for patient with SLE. Objectives: The aim of the current study was to assess the effect of depressive and anxiety on HRQoL in a cohort of patients with systemic lupus erythematosus in Russian Federation (RENAISSANCE). Methods: Consecutive patients who fulfilled SLICC 2012 criteria for SLE were recruited. Depressive and anxiety symptoms were assessed by the Hospital Anxiety and Depression (HAD) scale (0-21 points). Health-related quality of life (HRQoL) was assessed by the validated specific questionnaires LupusQoL-Russian. Disease activity was evaluated by the SLEDAI-2K, and chronic damage by the Systemic Lupus International Collaborating Clinics Damage Index score (SDI). Results: 328 Russian SLE patients were enrolled in the study (M/F 30/298, mean age 34.4±11.5 years, mean disease duration 106.3±97.9 months; mean SLEDAI 2K 9.6±8.0; mean SDI 0.2±0.6. 34 (10,3%) patients had HADS-depression score of ≥10 and 76 (23,1%) of patients had HADS-anxiety score of ≥10. Patients with depressive score of ≥10 had significantly lower the scales “Planning”, “Emotion health” and “Fatigue” (p<0,0001) of the LupusQoL than those with score <10. Similarly, significant lower “Emotion health” and “Fatigue” (p<0,0001) were noted in those patients with HAD-anxiety score ≥10 compared to those <10 and they also had low score of “Burden to others” unlike those who are not anxiety. (Table 1). Conclusion: Depressive and anxiety symptoms in SLE patients and were associated with significantly poorer HRQoL.Table 1 Effect of anxiety and depressive on HRQoL in SLE patient LupusQol domains HADS-anxiety< 10 HADS-anxiety ≥ 10 p HADS –depressive< 10 HADS-depressive ≥ 10 p Physical health 70,3±22,2 50,2±21,2 <0,0001 67,9±23,1 48,2±18,7 <0,0001 Pain 73,8±23,3 52±22,3 <0,0001 71,2±23,8 50,7±26,9 <0,0001 Planning 68,4±26,8 42,8±26,3 <0,0001 65,8±21,2 35,3±21,2 <0,0001 Intimate relationship 75,9±30,6 56,7±29,8 <0,0001 73,2±31,1 58,3±33,6 0,05 Burden to others 60,4±27,2 39,5±23,1 <0,0001 57,7±27,3 42±29,9 0,001 Emotion health 70,8±21,2 37,9±22 <0,0001 66,6±24,2 40,1±20,3 <0,0001 Body image 69,8±25,7 48±27,6 <0,0001 67±26,8 45,7±28,6 0,001 Fatigue 67,9±22,4 40±22,4 <0,0001 64,4±24,3 41±21,7 <0,0001 Disclosure of Interests: None declared