LAUSR

Background: Diabetes mellitus (DM), a worldwide high prevalence disease, is associated with a large variety of musculoskeletal (MS) disorders. They are poorly treated, as compared to microvascular complications. However, they are a common source of disability. Objectives: We designed this study to assess the prevalence of MS disorders among diabetic patients and their relation to microvascular complications of diabetes. Methods: A cross-sectional study enrolled consecutive subjects with diabetes seen in the Endocrinology department. We recorded age of patients, sex, body mass index, type and duration of diabetes, Long-term glycemic control assessed by hemoglobin A1c levels, and lipid profile. Musculoskeletal and microvascular disorders assessment was done by detailed history with clinical examinations and investigations if needed. Results: A total of 376 subjects were studied, (84.6% had type 2 diabetes). The mean age was 52.5±13.9 years, 41% had one or more microvascular complications, among which retinopathy was present in 28.2%, nephropathy in 16.1% and neuropathy in 12.8%. Moreover, 23.4% of the patients had one or more musculoskeletal disorders. Shoulder capsulitis was present in 12.5%; carpal tunnel syndrome in 8.8%; trigger finger in 5.9%; and 2.9% had diabetic cheiroarthropathy. Dupuytren’s contracture and Charcot foot, were found in 0.5% and 0.3% of the cases respectively. Symptomatic osteoarthritis was found in 19.4%. Musculoskeletal disorders prevalence increased with age, diabetes duration, presence of dyslipidemia and various microvascular complications.Abstract THU0460 –Table 1 Distribution of cases according to MS disorders in relation to type of diabetes MS disorders Type of diabetes Total N =376 Type 1 N = 58 Type 2 N = 318 P No. % No. % % No. % Osteoarthritis 2 3.4 71 22.3 0.001* 73 14.9 Shoulder capsulitis 2 3.4 45 14.2 0.023* 47 12.5 Carpel Tunnel Syndrome 5 8.6 28 8.8 0.969 33 8.8 Limited joint mobility 0 0 11 3.5 0.151 11 2.9 Trigger Finger 2 3.4 20 6.3 0.397 22 5.9 Dupuytren’s contracture 0 0 2 0.6 0.545 2 0.5 Charcot’s Foot Total MS disorders 110 1.717.2 078 024.5 0.1540.149 188 0.323.4 Conclusion: this study shows a high prevalence of musculoskeletal disorders in diabetic’s patients which were significantly associated with advanced age, longer duration of diabetes, presence of dyslipidemia and microvascular complications. Disclosure of Interests: : None declared