LAUSR

Background Sarcoidosis is a systemic disorder of unknown etiology, affecting the respiratory tract and the lymphatic system with predilection. It is an ubiquitous condition whose clinical phenotype is very diverse. Objectives To detail the epidemiological, clinico-biological, therapeutic and evolutionary features of osteoarticular forms of sarcoidosis. Methods This is a monocentric, descriptive retrospective study conducted over a 17-years period [2002-2018] involving 13 patients diagnosed with sarcoidosis with osteoarticular manifestations at the department of Rheumatology at Farhat Hached University Hospital in Sousse. Results 13 patients with osteoarticular manifestations were studied; this was indicative of the disease in 8 cases (61.5%). The sex ratio was 0.23 with a mean age of 42.38 years and a diagnostic delay of 12 months. In 77% of cases, inflammatory arthralgia was noted, Löfgren syndrome (30.7%), chronic polyarthritis (30.7%), phalanges cystoid osteitis (15.4%) and no cases of monoarthritis. The extra articular manifestations found were; Adenomegaly (92.3%), lung (77%), cutaneous (38.5%) (including 80% erythema nodosum), neurological (30.7%) (Aseptic meningitis and convulsion), ocular (23%) (chorioretinitis, keratoconjunctivitis and retro-bulbar optic neuritis), cardiac (15.4%), and biological hepatitis (7.7%). In the biology, a biological inflammatory syndrome was found in 30.7% with a mean sedimentation rate of 31.07 in the 1st hour, an average CRP of 9 mg/L, cholestasis and cytolysis found in 15.4% and 7.7%, respectively. No Hypercalcemia was noted. The value of the conversion enzyme was high in 5 out of 6 patients who were dosed with an average of 71 μg/L. In imaging, sarcoidosis was destructive in 4 cases; A multifocal osteonecrosis, Algodystrophy of the two hips and two cases of bullous cystoid osteitis of phalanges. Conclusion The osteo-articular involvement of sarcoidosis is polymorphic, which can reveal the disease or enamel its evolution. Disclosure of Interests None declared