LAUSR

Background: Behcet’s disease (BD) is a multisystem vasculitis with unknown etiology and a unique geographical distribution. Intestinal manifestations of BD (IBD) are of particular importance as they are associated with significant morbidity and mortality. Although ileocecal involvement is most commonly described, BD may involve any segment of the intestinal tract as well as the various organs within the gastrointestinal system. Objectives: To analyze the severity and clinical features IBD in Russia Methods: The study included 250 patients (male – 177, female – 73) with BD (according to ISGBD 1990 and ICBD criteria 2014). The male-to-female ratio was 2,4:1, the mean age was 31,5±9,3 yrs, the age of disease onset - 21.8±9.62 yrs, the median of disease duration - 10.25±8.32 yrs. All those with gastrointestinal symptoms were subject to a gastroscopy and/or colonoscopy through which Crohn’s disease and ulcerative colitis were excluded by the proctologists. Results: Patients with gastrointestinal symptoms were 63 of 250 - 25.2% pts, (male – 40, female – 23). Symptoms of IBD include the abdominal pain in 62% pts, distension –55%, diarrhea – 14%, nausea – 13%, blood in the bowel movement – 4,7%. The examination revealed: esophageal ulcers (1.6%, four cases), gastric ulcers (3.2%, eight cases), and duodenal ulcers (1.2%, three cases) were found using endoscopy. Also, 6.8% (17 patients) had gastro duodenal ulcers and 14.3% (nine patients) combined gastrointestinal involvement including esophageal and had gastro duodenal ulcers. Colonic ulcers were detected in 9.2% (23 cases) by colonoscopy, two patients had multisegmental diffuse ulceration, three patients had in the sigmoid colon and of everyone else in the ileum. Ccolitis without ulcers found in 5,6% (14 cases). Two patients had a clinic of appendicitis, the operation found that the appendix is not inflamed. Two patients were 0.8% (were on treatment) urgently operated due to perforation of ulcers of the ileum, the woman held suturing of perforated ulcer, and a man - hemicolectomy. The last patient has a relaparotomy after 1 month and removal of the entire colon. Conclusion: The IBD in Russia is affected in 1/4 of patients, but heavy refractory forms not often. Disclosure of Interests: None declared