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Riociguat in systemic sclerosis: a potential for disease modification.

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We read with great interest the results of the recently published Riociguat Safety and Efficacy in Systemic Sclerosis (RISE-SSc) trial1 and believe that additional analyses could further elucidate the role… Click to show full abstract

We read with great interest the results of the recently published Riociguat Safety and Efficacy in Systemic Sclerosis (RISE-SSc) trial1 and believe that additional analyses could further elucidate the role of riociguat in systemic sclerosis (SSc). First, considering the pleiotropic (antifibrotic, anti-inflammatory and antiproliferative) actions of riociguat, an analysis of the radiographic findings [pattern- cellular non-specific interstitial pneumonia (NSIP), fibrotic NSIP or usual interstitial pneumonia (UIP); and …

Keywords: sclerosis; disease modification; sclerosis potential; riociguat systemic; potential disease; systemic sclerosis

Journal Title: Annals of the rheumatic diseases
Year Published: 2020

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