LAUSR

Background: Gout is the most common inflammatory arthritis worldwide with a diverse spectrum of clinical manifestations. Many studies indicated that gout is associated with hypertension, metabolic syndrome, chronic kidney disease and ischaemic heart diseases. Objectives: This study investigated the association between the compliance of urate-lowering agents (ULA) compliance and progression end-stage renal disease (ESRD) and all-cause mortality. Methods: We identified 53,917 patients with incident gout from 2002 to 2012. We followed up these patients till 31DEC2015. The primary data source was the National Health Insurance database of Taiwan. Proportion of days covered (PDC) was used to measure medication adherence. Patients with PDC≧80% more than two years defined adherence to ULA. Cox proportional hazards model was used to estimate difference and hazard ratios (HRs) for ESRD and all-cause mortality. Results: A total of 53,917 patients were included (figure 1). Patient with urate-lowering agent PDC≧80% more than 2 years were 2,371. After propensity score matched 1:4 with age, sex and comorbidities, PDC Conclusion: Gout patients with/without two years adherence of urate-lowering agents does not have an impact on ESRD and all-cause mortality. References: Nil Disclosure of Interests: : None declared