LAUSR

Background: There is controversy regarding the relationship between osteoarthritis (OA) and osteoporosis (OP). While OA may be associated with increased bone mineral density (BMD) due to increased weight, evidence exists that the incidence of OP may be increased in patients with OA. Objectives: To determine whether the prevalence of OP is increased in patients with OA, compared to age and sex-matched populations. Methods: We conducted a systematic literature review using the databases PubMed, Embase, Scopus, and Web of Science, including articles that that analysed the frequency, rate, prevalence, incidence, risk, or excess risk of OP in patients with OA compared to age and sex-matched comparison groups (controls). Articles with fewer than 200 participants, and those without controls were excluded. Two reviewers conducted title and abstract screening. Results: Of 2772 unique articles, 49 articles were chosen for full article screening, and 4 articles met the inclusion criteria of our present study. Data from 2 and 4 studies used OP in men and women, respectively. Other articles reported on BMD and not OP so they were excluded. In women, 998 participants with OA were compared with 1903 controls. The pooled estimate of the odds ratio for prevalence of OP vs general matched population was not statistically different (Figure 1). In men, 136 participants with OA were compared with 682 controls. The results did not show a statistically significant different in the frequency of OP in OA in men (Figure 2).Figure 1. Prevalence of OP in women with OA compared to controlsFigure 2. Prevalence of OP in men with OA compared to controls Conclusion: The frequency of OP in participants with OA was the same in both men and women compared to the matched controls. References: [1]Chang, C. B., Kim, T. K., Kang, Y. G., Seong, S. C., & Kang, S. B. (2014). Prevalence of osteoporosis in female patients with advanced knee osteoarthritis undergoing total knee arthroplasty. Journal of Korean Medical Science, 29(10), 1425-1431. [2]Liu, G., Peacock, M., Eilam, O., Dorulla, G., Braunstein, E., & Johnston, C. C. (1997). Effect of osteoarthritis in the lumbar spine and hip on bone mineral density and diagnosis of osteoporosis in elderly men and women. Osteoporosis International, 7(6), 564-569. [3]Schneider, D. L., Barrett-Connor, E., Morton, D. J., & Weisman, M. (2002). Bone mineral density and clinical hand osteoarthritis in elderly men and women: the Rancho Bernardo study. The Journal of Rheumatology, 29(7), 1467-1472. [4]Schneider, D. L., Bettencourt, R., & Barrett-Connor, E. (2006). Clinical utility of spine bone density in elderly women. Journal of Clinical Densitometry, 9(3), 255-260. Disclosure of Interests: Ali Ahmadi Pirshahid: None declared, Dongkeun Kim: None declared, Yueyang Li: None declared, Timothy Varghese: None declared, Janet Pope Grant/research support from: AbbVie, Bristol-Myers Squibb, Eli Lilly & Company, Merck, Roche, Seattle Genetics, UCB, Consultant of: AbbVie, Actelion, Amgen, Bayer, Boehringer Ingelheim, Bristol-Myers Squibb, Eicos Sciences, Eli Lilly & Company, Emerald, Gilead Sciences, Inc., Janssen, Merck, Novartis, Pfizer, Roche, Sandoz, Sanofi, UCB, Speakers bureau: UCB