LAUSR

Psoriatic arthritis (PsA) negatively impacts patients’ (pts) quality of life (QoL), with a high burden of pain, fatigue and psychological distress. The 12-item Psoriatic Arthritis Impact of Disease questionnaire (PsAID-12) is a validated measure of pt-reported disease impact.To analyse PsAID-12 score changes in the overall population and specific subgroups of interest, and assess correlation of these changes using Health Assessment Questionnaire Disability Index (HAQ-DI).PsABio (NCT02627768) is a multinational, prospective, observational study in pts with PsA receiving ustekinumab (UST) or a tumour necrosis factor inhibitor (TNFi) as a 1st/2nd/3rd-line biologic. Descriptive statistics, including 95% CI, are presented at baseline (BL) and 1 year. Linear regression, including propensity score (PS) adjustment for BL covariates, was used to compare change in PsAID-12 total from BL to 1 year between treatments. The relationship between changes in PsAID-12 and HAQ-DI was investigated using Spearman’s correlation.Data were available for 438 UST and 455 TNFi pts. From BL to 1 year, significant improvements were seen in total PsAID-12 scores and in all domains with both treatments (Figure 1). PS-adjusted treatment comparison showed no difference in total PsAID-12 improvement (regression coefficient [95% CI]: 0.14 [-0.22; 0.51], p=0.4433), or in any domain, except skin problems, which improved significantly more with UST than TNFi (-0.55 [-1.04, -0.06], p=0.0277). Improvements in PsAID-12 and HAQ-DI showed strong positive correlation with both treatments (UST: r=0.63, p<0.0001; TNFi: r=0.70, p<0.0001). Effectiveness was demonstrated with UST and TNFi in subgroups of interest, including biologic treatment line, sex and psoriasis extent (Table 1. next page).Treatment with IL-12/23 (UST) or TNF inhibitors significantly improved pt-reported disease impact at 1 year. PS-adjusted PsAID-12 improvements did not differ significantly between treatments, except skin problems (better with UST). Improvements in disease impact and physical functioning (HAQ-DI) were strongly correlated, emphasising the effect of these biologics on QoL in PsA pts.Figure 1.Table 1.PsAID-12 scores by BL characteristic subgroupMean (95% CI)USTTNFiBLUnadjusted change from BL at 1 year (LOCF)BLUnadjusted change from BL at 1 year (LOCF)Biologic line1st5.51(5.19; 5.82)-2.14(-2.49; -1.79)5.44(5.15; 5.72)-2.41(-2.72; -2.09)2nd6.05(5.69; 6.41)-2.14(-2.55; -1.72)5.57(5.19; 5.95)-2.37(-2.79; -1.94)3rd5.84(5.33; 6.35)-1.81(-2.45; -1.17)5.34(4.52; 6.15)-1.89(-2.62; -1.16)Sex*Male5.27(4.95; 5.59)-2.35(-2.70; -1.99)4.89(4.56; 5.23)-2.49(-2.83; -2.15)Female6.14(5.86; 6.43)-1.86(-2.20; -1.52)5.95(5.67; 6.23)-2.20(-2.53; -1.87)EnthesitisYes5.95(5.66; 6.24)-2.19(-2.51; -1.86)5.89(5.61; 6.17)-2.65(-2.98; -2.31)No5.51(5.19; 5.83)-1.98(-2.36; -1.59)4.99(4.65; 5.32)-2.02(-2.35; -1.68)Psoriasis BSA, %<35.66(5.32; 6.00)-1.60(-2.03; -1.18)4.97(4.63; 5.31)-1.89(-2.25; -1.52)3–105.44(5.05; 5.83)-2.16(-2.59; -1.74)5.78(5.43; 6.14)-2.99(-3.38; -2.59)>106.15(5.70; 6.60)-2.93(-3.43; -2.43)6.13(5.55; 6.71)-2.86(-3.49; -2.23)Joint involvement†Mono/oligoarticular5.07(4.56; 5.58)-1.96(-2.47; -1.45)4.82(4.38; 5.25)-2.18(-2.66; -1.70)Polyarticular5.98(5.75; 6.22)-2.21(-2.51; -1.92)5.78(5.52; 6.04)-2.47(-2.75; -2.18)FiRST score*<55.15(4.87; 5.44)-2.18(-2.50; -1.87)5.10(4.83; 5.36)-2.44(-2.71; -2.16)≥56.72(6.43; 7.00)-1.95(-2.38; -1.53)6.49(6.15; 6.83)-2.09(-2.57; -1.61)*At BL, female pts and pts with FiRST score ≥5 (chronic widespread pain) were significantly more impacted than male pts and pts with FiRST score <5, and remained significantly more impacted at 1 year. †Polyarticular pts were significantly more impacted at BL, but not 1 year.BSA, body surface area; CI, confidence interval; FiRST, Fibromyalgia Rapid Screening Tool; LOCF, last observation carried forwardThis study was funded by Janssen.Laure Gossec Consultant of: AbbVie, Amgen, Bioepis, Biogen, Bristol-Myers Squibb, Celgene, Galapagos, Gilead, Janssen, Lilly, Novartis, Pfizer, Samsung, Sanofi-Aventis, UCB, Grant/research support from: Amgen, Galapagos, Janssen, Lilly, Pfizer, Sandoz, Sanofi, Stefan Siebert Speakers bureau: AbbVie, Amgen (previously Celgene), Biogen, Janssen, Novartis, UCB, Consultant of: AbbVie, Janssen, UCB, Grant/research support from: Amgen (previously Celgene), Boehringer Ingelheim, Bristol-Myers Squibb, GSK, Janssen, Novartis, Pfizer, UCB, Paul Bergmans Shareholder of: Johnson & Johnson, Employee of: Janssen, Kurt de Vlam Speakers bureau: AbbVie, Amgen, Eli Lilly, Novartis, UCB, Paid instructor for: Amgen, Galapagos, UCB, Consultant of: Eli Lilly, Galapagos, Johnson & Johnson, Novartis, UCB, Grant/research support from: Celgene, Elisa Gremese: None declared, Beatriz Joven-Ibáñez Speakers bureau: AbbVie, Celgene, Janssen, MSD, Novartis, Pfizer, Tatiana Korotaeva Speakers bureau: AbbVie, Amgen, Biocad, Lilly, Janssen, MSD, Novartis, Novartis-Pfizer, Sandoz, UCB, Consultant of: AbbVie, Amgen, Biocad, Lilly, Janssen, MSD, Novartis, Novartis-Sandoz, Pfizer, UCB, Grant/research support from: Pfizer, Wim Noel Employee of: Janssen, Michael Nurmohamed Speakers bureau: AbbVie, Bristol-Myers Squibb, Celgene, Eli Lilly, Janssen, Menarini, MSD, Mundipharma, Pfizer, Roche, Sanofi, UCB, Consultant of: AbbVie, Bristol-Myers Squibb, Celgene, Eli Lilly, Galapagos, Janssen, Menarini, MSD, Mundipharma, Pfizer, Roche, Sanofi, UCB, Grant/research support from: AbbVie, Bristol-Myers Squibb, Celgene, Eli Lilly, Galapagos, Gilead, Janssen, Menarini, MSD, Mundipharma, Pfizer, Roche, Sanofi, UCB, Petros Sfikakis Consultant of: AbbVie, Actelion, Boehringer Ingelheim, Enorasis, Farmaserv-Lilly, Genesis, Gilead, Pfizer, MSD, Novartis, UCB, Grant/research support from: AbbVie, Amgen, Boehringer Ingelheim, Faran, Janssen, Pfizer, Roche, Elke Theander Employee of: Janssen, Josef S. Smolen Speakers bureau: AbbVie, Amgen, AstraZeneca, Astro, Bristol-Myers Squibb, Celgene, Celltrion, Chugai, Gilead, ILTOO, Janssen, Lilly, MSD, Novartis- Sandoz, Pfizer, Roche, Samsung, Sanofi, UCB, Grant/research support from: AbbVie, AstraZeneca, Lilly, Novartis, Roche.