LAUSR

Inflammatory response is a common physiological response that protects the host of many harmful stimuli such as toxins, local injuries and pathogens. Today, non-steroidal anti-inflammatory drugs are the most commonly prescribed for the treatment of many inflammatory treatments. However, long term administration of these NSAIDs causes many adverse effects, including gastrointestinal ulcers and bleeding and kidney damage. Therefore, the need for new anti-inflammatory drugs with fewer side effects is required.The aim of our study was to evaluate the anti-inflammatory activity of Cinnamomum verum (C. Verum) on rats while testing the dose effect and the typical effect of the solvent.The edema was induced by injection of carrageenan solution (CARR) in paw of rats according to the method of Winter et al, 1963. The measurements of volumes of right hind paw of each rat were taken before induction of edema and each 1 h, 2 h, 3 h, 4 h and 5 h after the injection of carrageenan. 7 groups of 6 rats received, one hour before the injection of the carrageenan, different treatment: G1= witness, G2=CARR + saline solution, G3= CARR+ Acetylsalicylic acid, G4= CARR + C. verum- MeOH 100, G5= CARR + C. verum- MeOH 300, G6= CARR + CARR + C. verum- EtOH 100 and G7= CARR + C.verum- EtOH 300.For this test, the volume of edema increases with time, this increase is greater in the group treated with saline solution than with the extracts of C.Verum and with Acetylsalicylic acid. The extracts of C. Verum administered intraperitoneally one hour before the injection of the carrageenan, reduced the edema in the third hour after.The interesting anti-inflammatory activity of Cinnamomum verum recorded in this work may at least in part support its popular use in traditional medicine [1, 2].[1]Mirza Muhammad Fahd Qadir, Attya Bhatti, Muhammad Usman Ashraf, Mansur Abdullah Sandhu, Sidrah Anjum, Peter John. Immunomodulatory and therapeutic role of Cinnamomum verum extracts in collagen-induced arthritic BALB/c mice. Inflammopharmacology 2018 Feb;26(1):157-170.[2]Heping Cao, Joseph F Urban Jr, Richard A Anderson. Cinnamon polyphenol extract affects immune responses by regulating anti- and proinflammatory and glucose transporter gene expression in mouse macrophages. J Nutr 2008 May;138(5):833-40.None declared