LAUSR

Review of Manley BJ, Arnolda GRB, Wright IMR, et al . Nasal high-flow therapy for newborn infants in special care nurseries. N Engl J Med 2019;380:2031–2040. Study design: An unblinded, multicentre, randomised non-inferiority trial. Allocation: Computer-generated block randomisation sequence with random-sized blocks. Setting: Nine Australian non-tertiary neonatal centres Patients: 754 neonates <24 hours of age, ≥31 weeks of gestation, weighing ≥ 1200g who required non-invasive ventilatory support. Intervention: Patients were randomised to receive either high-flow (HF) therapy or continuous positive airway pressure (CPAP) . Exclusion criteria included pre-randomisation CPAP for ≥ 2 hours, previous endotracheal intubation, a major congenital abnormality or clinician discretion. Primary outcome: …