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Multisystem inflammatory syndrome in children (MISC) is a systemic inflammatory condition seen in children following SARSCoV2 infection or exposure. Symptoms are highly variable and include fever, diarrhoea, cardiogenic shock, respiratory… Click to show full abstract
Multisystem inflammatory syndrome in children (MISC) is a systemic inflammatory condition seen in children following SARSCoV2 infection or exposure. Symptoms are highly variable and include fever, diarrhoea, cardiogenic shock, respiratory compromise and Kawasaki disease (KD)like features. 2 Compared with acute COVID19, MISC is characterised by distinct immune responses, including increased monocyte/macrophagederived cytokines such as interleukin (IL)6 and IL18, Tcellderived cytokines including IL10 and IL17A, and TRBV112 expressing T cells. 4 However, the relationship between MISCrelated immunophenotypes and clinical heterogeneity is unknown. We determined clinical associations of MISC immunophenotypes in a cohort of 76 MISC patients. All patients met the Letter
Journal Title: Annals of the Rheumatic Diseases
Year Published: 2022
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