LAUSR

The prevalence of vascular calcification in patients with advanced chronic kidney disease (CKD) is very high.1 It is thought that calciphylaxis and vascular calcification are a continuum of extraskeletal osteogenesis and the clinical manifestations depend on the location of the affected artery.2 3 Calciphylaxis is associated with high morbidity and mortality. It commonly involves legs, abdomen and gluteal region, and rarely locations such as breast4 and penis. Sodium thiosulfate therapy is frequently used for the treatment of calciphylaxis. However, the response rate is relatively low with only about 27% of patients showing complete resolution, and 1 year mortality remaining high at ~35% despite …