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Recurrent abducens nerve palsy and hypophosphatasia syndrome

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A 47-year-old woman presented with six episodes of horizontal binocular double vision over a 2-year period. CT imaging was significant for extensive dural calcification in the spine and calcification of… Click to show full abstract

A 47-year-old woman presented with six episodes of horizontal binocular double vision over a 2-year period. CT imaging was significant for extensive dural calcification in the spine and calcification of the skull base, likely involving Dorello’s canal. Biochemical testing revealed a persistently low alkaline phosphatase level. Recurrent nerve palsy may possibly be induced by mechanical compression of the sixth cranial nerve in Dorello’s canal from calcification due to hypophosphatasia syndrome.

Keywords: nerve palsy; recurrent abducens; abducens nerve; hypophosphatasia syndrome

Journal Title: BMJ Case Reports
Year Published: 2019

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