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Acute liver failure secondary to therapeutic paracetamol dosing in an extremely preterm neonate

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We report the first case of standard therapeutic dose paracetamol for patent ductus arteriosus closure causing acute liver failure in an extremely preterm infant. After 5 days of treatment, he… Click to show full abstract

We report the first case of standard therapeutic dose paracetamol for patent ductus arteriosus closure causing acute liver failure in an extremely preterm infant. After 5 days of treatment, he presented with jaundice, acute severe hepatitis and coagulopathy. Treatment with N-acetyl cysteine resulted in full recovery.

Keywords: paracetamol; liver failure; failure secondary; acute liver; extremely preterm

Journal Title: BMJ Case Reports
Year Published: 2022

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